The initial phase in the development of a migraine is still poorly understood. Here, we
describe a previously unknown signaling pathway between stressed neurons and trigeminal …

We introduce dynamic light scattering imaging (DLSI) to enable the wide-field measurement
of the speckle temporal intensity autocorrelation function. DLSI uses the full temporal …

Extracellular vesicles (EVs) are nanoparticles (30 to 1000 nm in diameter) surrounded by a
lipid-bilayer which carry bioactive molecules between local and distal cells and participate in …

Intravital or multiphoton microscopy and laser-speckle imaging have become popular
because they allow live monitoring of several processes during cerebral ischemia. Available …

Laser speckle contrast imaging (LSCI) is a real-time full-field non-invasive technique, which
is broadly applied to visualize blood flow in biomedical applications. In its foundation is the …

The use of laser speckle contrast imaging (LSCI) has expanded rapidly for characterizing the
motion of scattering particles. Speckle contrast is related to the dynamics of the scattering …

Background Pain is generally concomitant with an inflammatory reaction at the site where
the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal …

Optical coherence tomography (OCT) allows label-free imaging of red blood cell (RBC) flux
within capillaries with high spatio-temporal resolution. In this study, we utilized time-series …

Animal models of stroke are used extensively to study the mechanisms involved in the acute
and chronic phases of recovery following stroke. A translatable animal model that closely …

Quantitative measurements of intravascular microscopic dynamics, such as absolute blood
flow velocity, shear stress and the diffusion coefficient of red blood cells (RBCs), are …