Over the sixty years since Koshland initially formulated the classical mechanisms for retaining
and inverting glycosidases, researchers have assembled a large body of supporting …

Human pancreatic α-amylase (HPA) is responsible for degrading starch to malto-oligosaccharides,
thence to glucose, and is therefore an attractive therapeutic target for the treatment of …

Nicotinamide N-methyltransferase (NNMT) methylates nicotinamide to form 1-methylnicotinamide
(MNA) using S-adenosyl-L-methionine (SAM) as the methyl donor. The complexity of …

The ongoing COVID-19 pandemic has had great societal and health consequences. Despite
the availability of vaccines, infection rates remain high due to immune evasive Omicron …

Macrocyclisation provides a means of stabilising the conformation of peptides, often resulting
in improved stability, selectivity, affinity, and cell permeability. In this work, a new approach …

Unsaturated glucuronyl hydrolases (UGLs) from GH family 88 of the CAZy classification
system cleave a terminal unsaturated sugar from the oligosaccharide products released by …

Influenza A viruses pose a serious pandemic risk, while generation of efficient vaccines against
seasonal variants remains challenging. There is thus a pressing need for new treatment …

Peptide display technologies are a powerful method for discovery of new bioactive sequences,
but linear sequences are often very unstable in a biological setting. Macrocyclisation of …

Targeting chemokine signaling is an attractive avenue for the treatment of inflammatory
disorders. Tyrosine sulfation is an important post-translational modification (PTM) that enhances …

De novo macrocyclic peptides, derived using selection technologies such as phage and
mRNA display, present unique and unexpected solutions to challenging biological problems. …