Canonical (H3.1/H3.2) and noncanonical (H3.3) histone 3 K27M-mutant gliomas have unique
spatiotemporal distributions, partner alterations and molecular profiles. The contribution of …

Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental
states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal …

Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and
show exquisite regional and temporal specificity, suggesting a developmental context …

Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells.
Prognosis is strongly associated with molecular subgroup, although the driver mutations …

Ependymomas are aggressive brain tumors. Although drivers of supratentorial ependymoma
( ZFTA - and YAP1 -associated gene fusions) have been discovered, their functions remain …

High-grade gliomas with arginine or valine substitutions of the histone H3.3 glycine-34 residue
(H3.3G34R/V) carry a dismal prognosis, and current treatments, including radiotherapy …

Down syndrome (DS), caused by the triplication of human chromosome 21, leads to significant
alterations in brain development and is a major genetic cause of intellectual disability. …

Purpose. The majority of X-ray contrast agents (XCA) are made with iodine, but iodine-based
XCA (I-XCA) exhibit low contrast in high kVp X-rays due to iodine’s low atomic number (Z = …

While comparison of primary tumor and metastases has highlighted genomic heterogeneity
in colorectal cancer (CRC), previous studies have focused on a single metastatic site or …

Chromatin state plays a major role in controlling gene expression, and comparative analysis
of ChIP-seq data is key to understanding epigenetic regulation. We present chromswitch, …