Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization
from epithelial to mesenchymal phenotypes, which leads to functional changes in cell …

During cancer progression, some cells within the primary tumor may reactivate a latent
embryonic program known as epithelial-to-mesenchymal transition (EMT). Through EMT, …

Aberrant activation of a latent embryonic program - known as the epithelial-mesenchymal
transition (EMT) - can endow cancer cells with the migratory and invasive capabilities …

The epithelial-mesenchymal transition (EMT) is a key developmental program that is often
activated during cancer invasion and metastasis. We here report that the induction of an EMT …

Metastasis is a multistep process during which cancer cells disseminate from the site of
primary tumors and establish secondary tumors in distant organs. In a search for key regulators …

Loss of the epithelial adhesion molecule E-cadherin is thought to enable metastasis by
disrupting intercellular contacts—an early step in metastatic dissemination. To further investigate …

The epithelial-to-mesenchymal transition (EMT) produces cancer cells that are invasive,
migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to …

Regulatory networks orchestrated by key transcription factors (TFs) have been proposed to
play a central role in the determination of stem cell states. However, the master …

The metastatic spread of epithelial cancer cells from the primary tumor to distant organs mimics
the cell migrations that occur during embryogenesis. Using gene expression profiling, we …

The functional roles of SNPs within the 8q24 gene desert in the cancer phenotype are not
yet well understood. Here, we report that CCAT2, a novel long noncoding RNA transcript (…