Members of the Hedgehog (Hh) family of secreted signaling proteins function as potent short-range
organizers in animal development. Their range of action is limited by a C-terminal …

Throughout the eukaryotic lineage, small RNA silencing pathways protect the genome against
the deleterious influence of selfish genetic elements such as transposons. In animals an …

The function of tubular epithelial organs like the kidney and lung is critically dependent on
the length and diameter of their constituting branches. Genetic analysis of tube size control …

The number of cells in an organ is regulated by mitogens and trophic factors that impinge on
intrinsic determinants of proliferation and apoptosis. We here report the identification of an …

The development of air-filled respiratory organs is crucial for survival at birth. We used a
combination of live imaging and genetic analysis to dissect respiratory organ maturation in the …

The repression of transposable elements in eukaryotes often involves their transcriptional
silencing via targeted chromatin modifications. In animal gonads, nuclear Argonaute proteins …

Map-based positional cloning of Drosophila melanogaster genes is hampered by both the
time-consuming, error-prone nature of traditional methods for genetic mapping and the …

PIWI clade Argonaute proteins silence transposon expression in animal gonads. Their
target specificity is defined by bound ∼23- to 30-nucleotide (nt) PIWI-interacting RNAs (piRNAs) …

Photoreceptors (R cells) in the Drosophila retina connect to targets in three distinct layers of
the optic lobe of the brain: R1–R6 connect to the lamina, and R7 and R8 connect to distinct …

Iron is an essential element in many biological processes. In vertebrates, serum transferrin
is the major supplier of iron to tissues, but the function of additional transferrin-like proteins …