It has become clear that complex interactions underlie the relationship between the skeletal
and immune systems. This is particularly true for the development of immune cells in the …

Matrix-producing osteoblasts and bone-resorbing osteoclasts maintain bone homeostasis.
Osteoclasts are multinucleated, giant cells of hematopoietic origin formed by the fusion of …

NFATc1 has been characterized as a master regulator of nuclear factor κB ligand-induced
osteoclast differentiation. Herein, we demonstrate a novel role for NFATc1 as a positive …

Osteoclasts are derived from myeloid lineage cells, and their differentiation is supported by
various osteotropic factors, including the tumor necrosis factor (TNF) family member TNF-…

Osteoclast differentiation from hematopoietic precursors is controlled by the tumor necrosis
factor family member tumor necrosis factor-related activation-induced cytokine (TRANCE) via …

Leptospirosis is a spirochetal zoonosis that causes an acute febrile systemic illness in humans.
Leptospira sp. hemolysins have been shown to be virulence factors for the pathogenesis …

Osteoporosis and the associated risk of fracture are major clinical challenges in the elderly.
Telomeres shorten with age in most human tissues, including bone, and because telomere …

INTRODUCTION: Mineral trioxide aggregate has been widely used as a retrograde filling
material. The aim of this study was to evaluate the biological effects of a newly developed fast-…

A spontaneous mutation in Bruton's tyrosine kinase (Btk) induces a defect in B-cell development
that results in the immunodeficiency diseases X-linked agammaglobulinemia in humans …

Interleukin (IL)-33 is a recently described pro-inflammatory cytokine. Here we demonstrate IL-33
as a regulator of functional osteoclasts (OCs) from human CD14 + monocytes. IL-33 …