Objective While tocilizumab (TCZ) is known to increase low‐density lipoprotein (LDL)
cholesterol levels, it is unclear whether TCZ increases cardiovascular risk in patients with …

Background: Hyperuricemia and gout are associated with an increased risk of cardiovascular
disease. Xanthine oxidase inhibitors, allopurinol and febuxostat, are the mainstay of urate-…

Objective Rare but potentially life‐threatening cutaneous adverse reactions have been
associated with allopurinol, but population‐based data on the incidence and mortality of such …

Objective To provide guidance for the management of gout, including indications for and
optimal use of urate‐lowering therapy ( ULT ), treatment of gout flares, and lifestyle and other …

Currently, a director is classified as independent if he or she has neither financial nor familial
ties to the CEO or to the firm. We add another dimension: social ties. Using a unique data …

With the power conversion efficiency of binary polymer solar cells dramatically improved,
the thermal stability of the small-molecule acceptors raised the main concerns on the device …

A new method for the decarboxylative coupling of alkyl N-hydroxyphthalimide esters (NHP
esters) with aryl iodides is presented. In contrast to previous studies that form alkyl radicals …

Although there is strong evidence that bisphosphonates prevent certain types of osteoporotic
fractures, there are concerns that these medications may be associated with rare atypical …

Over the past decade, an increasing number of observational studies have examined the
effectiveness or safety of treatments for rheumatoid arthritis. Unlike randomized controlled trials …

Heritability and genome stability are shaped by meiotic recombination, which is initiated via
hundreds of DNA double-strand breaks (DSBs). The distribution of DSBs throughout the …