Neutrophils are recognized as important circulating effector cells in the pathophysiology of
severe coronavirus disease 2019 (COVID-19). However, their role within the inflamed lungs is …

Objectives Emerging evidence of dysregulation of the myeloid cell compartment urges
investigations on neutrophil characteristics in coronavirus disease 2019 (COVID‐19). We isolated …

Chemokines are an indispensable component of our immune system through the regulation
of directional migration and activation of leukocytes. CXCL8 is the most potent human …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

Neutrophils are the most abundant leukocytes in human blood and the first cells responding
to infection and injury. Due to their limited ex vivo lifespan and the impossibility to …

Patients with severe COVID-19 develop acute respiratory distress syndrome (ARDS) that
may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that …

The human chemokine stromal cell-derived factor-1 (SDF-1) or CXCL12 is involved in
several homeostatic processes and pathologies through interaction with its cognate G protein-…

Nelfinavir is an HIV protease inhibitor that has been widely prescribed as a component of
highly active antiretroviral therapy, and has been reported to exert in vitro antiviral activity …

Although glycosaminoglycan (GAG)–protein interactions are important in many physiological
and pathological processes, the structural requirements for binding are poorly defined. …

Background COVID-19-associated pulmonary aspergillosis (CAPA) is a severe superinfection
with the fungus Aspergillus affecting patients who are critically ill with COVID-19. The …