Extracellular vesicles (EVs) have recently attracted a great deal of interest as they may
represent a new biosignaling paradigm. According to the mode of biogenesis, size and …

Cells secrete around 30–1000 nm membrane-enclosed vesicles, of which members of the
subgroup between 30 and 100 nm are termed exosomes (EXs). EXs are released into the …

Background: Kidney diseases are worldwide public health problems with a high cost and
increasing incidence. By revealing the genetic and cellular mechanism behind mammalian …

Wnts are a family of secreted proteins that regulate multiple steps of neural development
and stem cell differentiation. Two of them, Wnt1 and Wnt5a, activate distinct branches of Wnt …

Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We
assess the role of progesterone on global stem cell function by serially transplanting mouse …

Germ cells are the foundation of an individual, since they generate the gametes and provide
the unique genome established through meiosis. The sex-specific fate of the germline in …

Aims The stage-dependent organization of the cardiomyocytes during formation of the
different layers of the developing ventricular wall is critical for the establishment of a functional …

α-Methylacyl-CoA racemase (Amacr) deficiency in humans leads to sensory motor neuronal
and liver abnormalities. The disorder is recessively inherited and caused by mutations in the …

Background The human sweat is a mixture of secretions from three types of glands: eccrine,
apocrine, and sebaceous. Eccrine glands open directly on the skin surface and produce …

The Müllerian duct (MD) is the anlage of the oviduct, uterus and upper part of the vagina, the
main parts of the female reproductive tract. Several wingless-type mouse mammary tumor …