Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP-binding …

Zebrafish (Danio rerio) larvae are widely recognized for studying host–pathogen interactions
in vivo because of their optical transparency, genetic manipulability, and translational …

Inactivation of the transcriptional regulator PhoP results in Mycobacterium tuberculosis
attenuation. Preclinical testing has shown that attenuated M. tuberculosis phoP mutants hold …

To better understand the evolution of the Mycobacterium tuberculosis complex, subspecies
were tested for large sequence polymorphisms. Samples with greater numbers of deletions, …

Autophagy is an important mechanism of innate immune defense. We have recently shown
that autophagy components are recruited with septins, a new and increasingly characterized …

Actin-based motility is used by various pathogens for dissemination within and between
cells. Yet host factors restricting this process have not been identified. Septins are GTP-binding …

MicroRNAs (miRNAs) form a class of short RNAs (∼ 21 nucleotides) that post-transcriptionally
regulate partially complementary messenger RNAs. Each miRNA may target tens to …

NOD2/CARD15 mediates innate immune responses to mycobacterial infection. However, its
role in the regulation of adaptive immunity has remained unknown. In this study, we …

L. monocytogenes is a facultative intracellular bacterium responsible for listeriosis. It is able
to invade, survive and replicate in phagocytic and non-phagocytic cells. The infectious …

Autophagy, an ancient and highly conserved intracellular degradation process, is viewed as
a critical component of innate immunity because of its ability to deliver cytosolic bacteria to …