To explore the role of Dicer-dependent control mechanisms in B lymphocyte development,
we ablated this enzyme in early B cell progenitors. This resulted in a developmental block at …

… Tet2 deficiency did not significantly alter the development of B cells and myeloid cells in
this experimental setting (Fig. S4B), and splenomegaly was observed in some mice …

Microaspiration is a common phenomenon in healthy subjects, but its frequency is
increased in chronic inflammatory airway diseases, and its role in inflammatory and immune …

Objective To investigate the humoral and cellular immune response to messenger RNA (mRNA)
COVID-19 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) …

A central challenge for improving autoimmune therapy is preventing inflammatory pathology
without inducing generalized immunosuppression. T helper 17 (T H 17) cells, characterized …

Multimodal single-cell assays provide high-resolution snapshots of complex cell populations,
but are mostly limited to transcriptome plus an additional modality. Here, we describe …

Despite mounting evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
engagement with immune cells, most express little, if any, of the canonical receptor of …

Multiple lines of investigation have shown that the gut microbiota affects host immune
response to immunotherapy in cancer. Here, we support that the local airway microbiota …

Antibodies' protective, pathological, and therapeutic properties result from their considerable
diversity. This diversity is almost limitless in potential, but actual diversity is still poorly …

Leptin-stimulated Stat3 activation in proopiomelanocortin (POMC)-expressing neurons of the
hypothalamus plays an important role in maintenance of energy homeostasis. While Stat3 …