[HTML][HTML] Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
S Marttila, L Kananen, S Häyrynen, J Jylhävä… - BMC genomics, 2015 - Springer
Background Changes in DNA methylation are among the mechanisms contributing to the
ageing process. We sought to identify ageing-associated DNA methylation changes at single-…
ageing process. We sought to identify ageing-associated DNA methylation changes at single-…
[HTML][HTML] Laminin α5 substrates promote survival, network formation and functional development of human pluripotent stem cell-derived neurons in vitro
A Hyysalo, M Ristola, MEL Mäkinen, S Häyrynen… - Stem cell …, 2017 - Elsevier
Laminins are one of the major protein groups in the extracellular matrix (ECM) and specific
laminin isoforms are crucial for neuronal functions in the central nervous system in vivo. In the …
laminin isoforms are crucial for neuronal functions in the central nervous system in vivo. In the …
Hemap: an interactive online resource for characterizing molecular phenotypes across hematologic malignancies
… Sergei Häyrynen … Sergei Häyrynen … Petri Pölönen, Juha Mehtonen, Jake Lin, Thomas
Liuksiala, Sergei Häyrynen, Susanna Teppo, Artturi Mäkinen, Ashwini Kumar, Disha Malani, Virva …
Liuksiala, Sergei Häyrynen, Susanna Teppo, Artturi Mäkinen, Ashwini Kumar, Disha Malani, Virva …
Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer
…, G Högnäs, S Häyrynen… - Molecular …, 2016 - molecularcasestudies.cshlp.org
We report the first combined analysis of whole-genome sequence, detailed clinical history,
and transcriptome sequence of multiple prostate cancer metastases in a single patient (A21). …
and transcriptome sequence of multiple prostate cancer metastases in a single patient (A21). …
Data-driven characterization of molecular phenotypes across heterogeneous sample collections
J Mehtonen, P Pölönen, S Häyrynen… - Nucleic acids …, 2019 - academic.oup.com
Existing large gene expression data repositories hold enormous potential to elucidate disease
mechanisms, characterize changes in cellular pathways, and to stratify patients based on …
mechanisms, characterize changes in cellular pathways, and to stratify patients based on …
[HTML][HTML] Comparison of machine learning methods in the early identification of vasculitides, myositides and glomerulonephritides
R Ryyppö, S Häyrynen, H Joutsijoki, M Juhola… - Computer Methods and …, 2024 - Elsevier
Background Rare disease diagnoses are often delayed by years, including multiple doctor
visits, and potential imprecise or incorrect diagnoses before receiving the correct one. …
visits, and potential imprecise or incorrect diagnoses before receiving the correct one. …
CYP2C19 loss‐of‐function alleles and use of omeprazole or esomeprazole increase the risk of cardiovascular outcomes in patients using clopidogrel
M Ramste, M Ritvos, S Häyrynen… - Clinical and …, 2023 - Wiley Online Library
Our aim was to investigate in a real‐life prospective patient cohort how CYP2C19 loss‐of‐function
(LOF) variants and CYP2C19 inhibitor omeprazole or esomeprazole influence the …
(LOF) variants and CYP2C19 inhibitor omeprazole or esomeprazole influence the …
Bone morphogenetic protein 4 regulates micro RNA expression in breast cancer cell lines in diverse fashion
EL Alarmo, R Havunen, S Häyrynen… - Genes …, 2016 - Wiley Online Library
Bone morphogenetic protein 4 (BMP4) is a remarkably powerful inhibitor of breast cancer
cell proliferation, but it is also able to induce breast cancer cell migration in certain cellular …
cell proliferation, but it is also able to induce breast cancer cell migration in certain cellular …
[HTML][HTML] Challenges and opportunities for strain verification by whole-genome sequencing
Laboratory strains, cell lines, and other genetic materials change hands frequently in the life
sciences. Despite evidence that such materials are subject to mix-ups, contamination, and …
sciences. Despite evidence that such materials are subject to mix-ups, contamination, and …
Whole-exome sequencing identifies germline mutation in TP53 and ATRX in a child with genomically aberrant AT/RT and her mother with anaplastic astrocytoma
…, M Annala, S Häyrynen… - Molecular …, 2018 - molecularcasestudies.cshlp.org
Brain tumors typically arise sporadically and do not affect several family members simultaneously.
In the present study, we describe clinical and genetic data from two patients, a mother …
In the present study, we describe clinical and genetic data from two patients, a mother …