Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains
SV Ulianov, EE Khrameeva, AA Gavrilov… - Genome …, 2016 - genome.cshlp.org
Recent advances enabled by the Hi-C technique have unraveled many principles of chromosomal
folding that were subsequently linked to disease and gene regulation. In particular, Hi-…
folding that were subsequently linked to disease and gene regulation. In particular, Hi-…
Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition
Chromatin is reprogrammed after fertilization to produce a totipotent zygote with the potential
to generate a new organism 1 . The maternal genome inherited from the oocyte and the …
to generate a new organism 1 . The maternal genome inherited from the oocyte and the …
[HTML][HTML] Order and stochasticity in the folding of individual Drosophila genomes
SV Ulianov, VV Zakharova, AA Galitsyna, PI Kos… - Nature …, 2021 - nature.com
Mammalian and Drosophila genomes are partitioned into topologically associating domains
(TADs). Although this partitioning has been reported to be functionally relevant, it is unclear …
(TADs). Although this partitioning has been reported to be functionally relevant, it is unclear …
SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties
…, MD Magnitov, L Del Maestro, SV Ulianov… - Nucleic Acids …, 2022 - academic.oup.com
Imbalance in the finely orchestrated system of chromatin-modifying enzymes is a hallmark
of many pathologies such as cancers, since causing the affection of the epigenome and …
of many pathologies such as cancers, since causing the affection of the epigenome and …
[HTML][HTML] Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
SV Ulianov, SA Doronin, EE Khrameeva, PI Kos… - Nature …, 2019 - nature.com
How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood.
Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and …
Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and …
Suppression of liquid–liquid phase separation by 1, 6-hexanediol partially compromises the 3D genome organization in living cells
SV Ulianov, AK Velichko, MD Magnitov… - Nucleic acids …, 2021 - academic.oup.com
Liquid–liquid phase separation (LLPS) contributes to the spatial and functional segregation
of molecular processes within the cell nucleus. However, the role played by LLPS in …
of molecular processes within the cell nucleus. However, the role played by LLPS in …
[HTML][HTML] The nuclear lamina as an organizer of chromosome architecture
YY Shevelyov, SV Ulianov - Cells, 2019 - mdpi.com
The nuclear lamina (NL) is a meshwork of lamins and lamin-associated proteins adjoining
the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses …
the inner side of the nuclear envelope. In early embryonic cells, the NL mainly suppresses …
Studying RNA–DNA interactome by Red-C identifies noncoding RNAs associated with various chromatin types and reveals transcription dynamics
…, MD Logacheva, OL Kantidze, SV Ulianov… - Nucleic Acids …, 2020 - academic.oup.com
Non-coding RNAs (ncRNAs) participate in various biological processes, including regulating
transcription and sustaining genome 3D organization. Here, we present a method termed …
transcription and sustaining genome 3D organization. Here, we present a method termed …
CRISPR/Cas9-generated mouse model of Duchenne muscular dystrophy recapitulating a newly identified large 430 kb deletion in the human DMD gene
…, AA Gavrilov, SV Ulianov… - Disease Models & …, 2019 - journals.biologists.com
Exon skipping is a promising strategy for Duchenne muscular dystrophy (DMD) disease-modifying
therapy. To make this approach safe, ensuring that excluding one or more exons will …
therapy. To make this approach safe, ensuring that excluding one or more exons will …
[HTML][HTML] Gene functioning and storage within a folded genome
SV Razin, SV Ulianov - Cellular & molecular biology letters, 2017 - Springer
In mammals, genomic DNA that is roughly 2 m long is folded to fit the size of the cell nucleus
that has a diameter of about 10 μm. The folding of genomic DNA is mediated via assembly …
that has a diameter of about 10 μm. The folding of genomic DNA is mediated via assembly …