Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal
myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the …

… Author links open overlay panel Luca Antonioli 1 2 , Sergey V. Novitskiy 3 , Kris F.
Sachsenmeier 4 , Matteo Fornai 1 , Corrado Blandizzi 1 , György Haskó 2 …

Dendritic cells (DCs), a type of professional antigen-presenting cells, are responsible for
initiation and maintenance of immune responses. Here we report that a substantial proportion of …

Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to
patient mortality, yet antistromal therapies are controversial. We found that human PDACs with …

Differentiation of functional dendritic cells (DCs) critically depends on the microenvironment.
DCs differentiate in hypoxic tumor sites and inflamed or damaged tissue. Because local …

Extracellular adenosine and purine nucleotides are elevated in many pathological situations
associated with the expansion of CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs). …

Vascular endothelial growth factor (VEGF), a major factor in tumor-host interactions, plays a
critical role in the aberrant hematopoiesis observed in cancer-bearing hosts. To dissect the …

Cancer-associated fibroblasts (CAFs) are highly prominent in breast tumors, but their
functional heterogeneity and origin are still largely unresolved. We report that bone marrow (BM)–…

Recent studies suggest that tumor-infiltrating immune cells can benefit the tumor by
producing factors that promote angiogenesis and suppress immunity. Because the tumor …

(Cancer Cell 28, 623–637; November 9, 2015) In the originally published version of this
paper, the authors inadvertently omitted an important funding source in the Acknowledgments. …