Chromatin is reprogrammed after fertilization to produce a totipotent zygote with the potential
to generate a new organism 1 . The maternal genome inherited from the oocyte and the …

Recent advances enabled by the Hi-C technique have unraveled many principles of chromosomal
folding that were subsequently linked to disease and gene regulation. In particular, Hi-…

To date, dozens of stress‐induced cellular senescence phenotypes have been reported.
These cellular senescence states may differ substantially from each other, as well as from …

Heat shock (HS) is one of the best-studied exogenous cellular stresses. The cellular response
to HS utilizes ancient molecular networks that are based primarily on the action of stress-…

Compartmentalization and compaction of DNA in the nucleus is the characteristic feature of
eukaryotic cells. A fully extended DNA molecule has to be compacted 100,000 times to fit …

The nucleolus is the largest and most studied nuclear body, but its role in nuclear function is
far from being comprehensively understood. Much work on the nucleolus has focused on its …

How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood.
Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and …

Mammalian and Drosophila genomes are partitioned into topologically associating domains
(TADs). Although this partitioning has been reported to be functionally relevant, it is unclear …

Synthetic lethality occurs when simultaneous perturbations of two genes or molecular processes
result in a loss of cell viability. The number of known synthetically lethal interactions is …

Liquid–liquid phase separation (LLPS) contributes to the spatial and functional segregation
of molecular processes within the cell nucleus. However, the role played by LLPS in …