Molecular mechanisms of copper uptake and distribution

S Puig, DJ Thiele - Current opinion in chemical biology, 2002 - Elsevier
In the past few years, exciting advances have been made toward understanding how copper
is transported into and distributed to cupro-proteins within cells. Recent work has identified …

[HTML][HTML] Biochemical and genetic analyses of yeast and human high affinity copper transporters suggest a conserved mechanism for copper uptake

S Puig, J Lee, M Lau, DJ Thiele - Journal of Biological Chemistry, 2002 - ASBMB
The redox active metal copper is an essential cofactor in critical biological processes such
as respiration, iron transport, oxidative stress protection, hormone production, and …

[HTML][HTML] Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation

S Puig, E Askeland, DJ Thiele - Cell, 2005 - cell.com
Iron (Fe) is an essential micronutrient for virtually all organisms and serves as a cofactor for
a wide variety of vital cellular processes. Although Fe deficiency is the primary nutritional …

[HTML][HTML] Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae

T Jordá, S Puig - Genes, 2020 - mdpi.com
Ergosterol is an essential component of fungal cell membranes that determines the fluidity,
permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a …

The Arabidopsis heavy metal P‐type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots

…, S Mayo, DJ Thiele, JR Ecker, S Puig… - The Plant …, 2006 - Wiley Online Library
Since copper (Cu) is essential in key physiological oxidation reactions, organisms have
developed strategies for handling Cu while avoiding its potentially toxic effects. Among the tools …

Identification of a copper transporter family in Arabidopsis thaliana

V Sancenón, S Puig, H Mira, DJ Thiele… - Plant molecular …, 2003 - Springer
Despite copper ions being crucial in proteins participating in plant processes such as electron
transport, free-radical elimination and hormone perception and signaling, very little is …

Copper and iron homeostasis in Arabidopsis: responses to metal deficiencies, interactions and biotechnological applications

S Puig, N ANDRÉS‐COLÁS… - Plant, cell & …, 2007 - Wiley Online Library
Plants have developed sophisticated mechanisms to tightly control the acquisition and
distribution of copper and iron in response to environmental fluctuations. Recent studies with …

[HTML][HTML] The Arabidopsis copper transporter COPT1 functions in root elongation and pollen development

V Sancenón, S Puig, I Mateu-Andrés, E Dorcey… - Journal of Biological …, 2004 - ASBMB
Copper plays a dual role in aerobic organisms, as both an essential and a potentially toxic
element. To ensure copper availability while avoiding its toxic effects, organisms have …

Molecular characterization of a chromosomal rearrangement involved in the adaptive evolution of yeast strains

JE Pérez-Ortın, A Querol, S Puig, E Barrio - Genome research, 2002 - genome.cshlp.org
Wine yeast strains show a high level of chromosome length polymorphism. This polymorphism
is mainly generated by illegitimate recombination mediated by Ty transposons or …

The elemental role of iron in DNA synthesis and repair

S Puig, L Ramos-Alonso, AM Romero… - Metallomics, 2017 - academic.oup.com
Iron is an essential redox element that functions as a cofactor in many metabolic pathways.
Critical enzymes in DNA metabolism, including multiple DNA repair enzymes (helicases, …