The biochemistry of somatic hypermutation
…, FL Kuang, MD Iglesias-Ussel, S Roa… - Annu. Rev …, 2008 - annualreviews.org
Affinity maturation of the humoral response is mediated by somatic hypermutation of the
immunoglobulin (Ig) genes and selection of higher-affinity B cell clones. Activation-induced …
immunoglobulin (Ig) genes and selection of higher-affinity B cell clones. Activation-induced …
[HTML][HTML] Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma
(MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we …
(MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we …
[HTML][HTML] Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells
…, SL Allen, KR Rai, I Ivanovic, IM Dozmorov, S Roa… - Molecular …, 2011 - Springer
The failure of chemotherapeutic regimens to eradicate cancers often results from the
outgrowth of minor subclones with more dangerous genomic abnormalities or with self-renewing …
outgrowth of minor subclones with more dangerous genomic abnormalities or with self-renewing …
[HTML][HTML] Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies
…, JA Sanchez-Arias, E Miranda, A Ugarte, S Roa… - Nature …, 2017 - nature.com
The indisputable role of epigenetics in cancer and the fact that epigenetic alterations can be
reversed have favoured development of epigenetic drugs. In this study, we design and …
reversed have favoured development of epigenetic drugs. In this study, we design and …
Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
Somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes are dependent
upon activation-induced cytidine deaminase (AID)-induced mutations. The scaffolding …
upon activation-induced cytidine deaminase (AID)-induced mutations. The scaffolding …
PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas
Refractory or relapsed diffuse large B-cell lymphoma (DLBCL) often associates with the
activated B-cell-like (ABC) subtype and genetic alterations that drive constitutive NF-κB …
activated B-cell-like (ABC) subtype and genetic alterations that drive constitutive NF-κB …
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
JMM Van Oers, S Roa, U Werling… - Proceedings of the …, 2010 - National Acad Sciences
The DNA mismatch repair protein PMS2 was recently found to encode a novel endonuclease
activity. To determine the biological functions of this activity in mammals, we generated …
activity. To determine the biological functions of this activity in mammals, we generated …
Downregulation of FOXP1 is required during germinal center B-cell function
…, JI Martinez-Ferrandis, S Roa… - Blood, The Journal …, 2013 - ashpublications.org
B-cell maturation and germinal center (GC) formation are dependent on the interplay between
BCL6 and other transcriptional regulators. FOXP1 is a transcription factor that regulates …
BCL6 and other transcriptional regulators. FOXP1 is a transcription factor that regulates …
Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes
Mammalian Exonuclease 1 (EXO1) is an evolutionarily conserved, multifunctional exonuclease
involved in DNA damage repair, replication, immunoglobulin diversity, meiosis, and …
involved in DNA damage repair, replication, immunoglobulin diversity, meiosis, and …
IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions
…, JE Kolitz, SL Allen, KR Rai, S Roa… - Blood, The Journal …, 2012 - ashpublications.org
Clonal evolution occurs during the course of chronic lymphocytic leukemia (CLL) and
activation-induced deaminase (AID) could influence this process. However, this possibility has …
activation-induced deaminase (AID) could influence this process. However, this possibility has …