Recent investigations suggest that sex hormones play an important role in the brown
adipose tissue (BAT) thermogenic program by acting on several steps of the lipolytic signal …

Gender-related differences in the brown adipose tissue (BAT) response to overfeeding rats
on a cafeteria diet were studied by assessing the balance between the expression of β-…

Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating
food intake; however, confirmation that it is a physiologically relevant regulatory system …

Thyroid hormones have widespread cellular effects; however it is unclear whether their
effects on the central nervous system (CNS) contribute to global energy balance. Here we …

Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also
relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and, …

Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both
functions are dependent on the development of the senescent phenotype, which involves an …

Brown adipose tissue (BAT) thermogenesis is inhibited during late-pregnancy and lactation
in the rat. However, scarce information concerning BAT functionality during mid-pregnancy is …

Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk 1 , 2 . More than 60% of this effect is attributable to the …

Identification of early mechanisms that may lead from obesity towards complications such as
metabolic syndrome is of great interest. Here we performed lipidomic analyses of adipose …

Control of mitochondrial biogenesis in brown adipose tissue (BAT), as part of the thermogenesis
program, is a complex process that requires the integration of multiple transcription …