Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

We assembled a semi-automated reconstruction of L2/3 mouse primary visual cortex from ∼250
× 140 × 90 μm 3 of electron microscopic images, including pyramidal and non-…

Due to advances in automated image acquisition and analysis, whole-brain connectomes
with 100,000 or more neurons are on the horizon. Proofreading of whole-brain automated …

To understand the brain we must relate neurons’ functional responses to the circuit architecture
that shapes them. Here, we present a large functional connectomics dataset with dense …

Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological,
molecular, and connectivity signatures. While considerable work has measured the average …

Connections between neurons can be mapped by acquiring and analyzing electron microscopic
(EM) brain images. In recent years, this approach has been applied to chunks of brains …

Synapses between excitatory neurons in the cortex and hippocampus are typically made onto
spines, tiny thorn-like protrusions from dendrites (Yuste, 2010). In the 2000s, long-term in …

Mammalian cortex features a large diversity of neuronal cell types, each with characteristic
anatomical, molecular and functional properties. Synaptic connectivity rules powerfully shape …

We present a semi-automated reconstruction of L2/3 mouse primary visual cortex from 3
million cubic microns of electron microscopic images, including pyramidal and inhibitory …

The activity and connectivity of inhibitory cells has a profound impact on the operation of
neuronal networks. While the average connectivity of many inhibitory cell types has been …