Fueled by the explosion of (meta)genomic data, genome mining of specialized metabolites
has become a major technology for drug discovery and studying microbiome ecology. In …

Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups 1 , this diversity encompasses a rich discovery potential …

Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …

The global atmospheric level of methane (CH 4 ), the second most important greenhouse
gas, is currently increasing by ∼10 million tons per year. Microbial oxidation in unsaturated …

Organisms throughout the tree of life accumulate chemical resources, in particular forms or
compartments, to secure their availability for future use. Here we review microbial storage …

Conservation of a molecular target across species can be used as a line-of-evidence to predict
the likelihood of chemical susceptibility. The web-based Sequence Alignment to Predict …

Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and
pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been …

Lipopeptides represent a large group of microbial natural products that include important
antibacterial and antifungal drugs and some of the most-powerful known biosurfactants. The …

Developments in computational omics technologies have provided new means to access the
hidden diversity of natural products, unearthing new potential for drug discovery. In parallel…

Biodegradation is simply the metabolism of anthropogenic, or otherwise unwanted,
chemicals in our environment, typically by microorganisms. The metabolism of compounds …