Structure of human Fe–S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP–ISD11 interactions
SA Cory, JG Van Vranken… - Proceedings of the …, 2017 - National Acad Sciences
In eukaryotes, sulfur is mobilized for incorporation into multiple biosynthetic pathways by a
cysteine desulfurase complex that consists of a catalytic subunit (NFS1), LYR protein (ISD11), …
cysteine desulfurase complex that consists of a catalytic subunit (NFS1), LYR protein (ISD11), …
Structure and Chemical Reaction Mechanism of LigU, an Enzyme That Catalyzes an Allylic Isomerization in the Bacterial Degradation of Lignin
TN Hogancamp, SA Cory, DP Barondeau… - Biochemistry, 2019 - ACS Publications
LigU from Novosphingobium sp. strain KA1 catalyzes the isomerization of (4E)-oxalomesaconate
(OMA) to (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) as part of the protocatechuate (…
(OMA) to (3Z)-2-keto-4-carboxy-3-hexenedioate (KCH) as part of the protocatechuate (…
Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model
Iron-sulfur (Fe-S) clusters have a key role in many biochemical processes and are essential
for most life forms. Despite recent mechanistic advances in understanding the Fe-S cluster …
for most life forms. Despite recent mechanistic advances in understanding the Fe-S cluster …
Structure, Function, and Regulation of the Human Fe-S Cluster Biosynthetic Subcomplex
SA Cory - 2019 - oaktrust.library.tamu.edu
Iron-sulfur (Fe-S) clusters are inorganic cofactors found throughout all domains of life. These
clusters are often ligated to proteins allowing Fe-S clusters to participate in a variety of …
clusters are often ligated to proteins allowing Fe-S clusters to participate in a variety of …
Frataxin Traps Low Abundance Quaternary Structure to Stimulate Human Fe-S Cluster Biosynthesis
Iron-sulfur clusters are essential protein cofactors synthesized in human mitochondria by an
NFS1-ISD11-ACP-ISCU2-FXN assembly complex. Surprisingly, researchers have …
NFS1-ISD11-ACP-ISCU2-FXN assembly complex. Surprisingly, researchers have …
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an …
…, IC Northwood, FA Gonzalez, DA Latour, A Seth… - Journal of Biological …, 1991 - ASBMB
A growth factor-stimulated (MAP2-related) protein kinase, ERT, that phosphorylates the
epidermal growth factor receptor at Thr669 has been purified from KB human tumor cells by …
epidermal growth factor receptor at Thr669 has been purified from KB human tumor cells by …
Antileukemic properties of the kinase inhibitor OTSSP167 in T-cell acute lymphoblastic leukemia
CS Bridges, TJ Chen, M Puppi, KR Rabin… - Blood …, 2023 - ashpublications.org
Novel drugs are needed to increase treatment response in children with high-risk T-cell acute
lymphoblastic leukemia (T-ALL). Following up on our previous report on the activation of …
lymphoblastic leukemia (T-ALL). Following up on our previous report on the activation of …
Pharmacological Inhibition of MAP2K7 Induces Apoptosis and Cell Cycle Arrest in T-Cell Acute Lymphoblastic Leukemia
TJ Chen, Y Shen, CS Bridges, CS Park, JJ Junco… - Blood, 2019 - Elsevier
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer and relapsed ALL
is a leading cause of cancer-related death in children. While advances in frontline therapy …
is a leading cause of cancer-related death in children. While advances in frontline therapy …
Methods to Their Madness: Understanding the Behavior of Rogue Regimes
CS Julie - 2013 - repository.library.georgetown.edu
Upon establishing a population of cases based on these criterion and situating rogue states
within the wider conventional wisdom on authoritarian survival, I develop a path-dependent …
within the wider conventional wisdom on authoritarian survival, I develop a path-dependent …
ASH2L Regulates Genes Involved in the Survival of Leukemic T Cells through a Loci-Specific H3K4me3 Landscape and Leukemogenesis Via Direct Gene Regulation
TJ Chen, CS Bridges, M Puppi, D Lacorazza - Blood, 2022 - ashpublications.org
Acute lymphoblastic leukemia (ALL) is a deadly blood cancer and the most common
hematological malignancy in pediatric patients. While treatment response has significantly …
hematological malignancy in pediatric patients. While treatment response has significantly …