Several independent lines of evidence suggest that megakaryocytes are dysfunctional in
severe COVID-19. Herein, we characterized peripheral circulating megakaryocytes in a large …

Vascular endothelial growth factor (VEGF)–neutralizing proteins provide benefit in several
retinal and choroidal vascular diseases, but some patients still experience suboptimal …

Sustained suppression of VEGF is needed in many patients with neovascular age-related
macular degeneration (NVAMD), and gene transfer of a VEGF-neutralizing protein is a …

Neutrophilic inflammation characterizes several respiratory viral infections, including COVID-19–related
acute respiratory distress syndrome, although its contribution to disease …

Clinical trials in patients with macular edema due to diabetic retinopathy or retinal vein
occlusion (RVO) have shown that suppression of VEGF not only improves macular edema, but …

Acriflavine, a fluorescent drug previously used for bacterial and trypanosomal infections,
reduces hypoxia-inducible factor-1 (HIF-1) and HIF-2 transcriptional activity. In mice with oxygen…

Tyrosine kinase inhibitors (TKIs) are very effective in treating chronic myelogenous leukemia
(CML), but primitive, quiescent leukemia stem cells persist as a barrier to the cure. We …

Retinopathy of prematurity (ROP) is a disorder of the developing retina of preterm infants.
ROP can lead to blindness because of abnormal angiogenesis that is the result of suspended …

In diabetic dyslipidemia, cholesterol accumulates in the plasma membrane, decreasing
fluidity and thereby suppressing the ability of cells to transduce ligand-activated signaling …

Human induced pluripotent stem cells (hiPSCs) were differentiated into a specific mesoderm
subset characterized by KDR + CD56 + APLNR + (KNA + ) expression. KNA + cells had …