Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous,
and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a …

Comprehensive and spatially mapped molecular atlases of organs at a cellular level are a
critical resource to gain insights into pathogenic mechanisms and personalized therapies for …

Single-cell sequencing studies have characterized the transcriptomic signature of cell types
within the kidney. However, the spatial distribution of acute kidney injury (AKI) is regional …

Sepsis is a dynamic state that progresses at variable rates and has life-threatening
consequences. Staging patients along the sepsis timeline requires a thorough knowledge of the …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods 1 . Here we …

Salmonella enterica is an intracellular bacterial pathogen that resides and proliferates
within a membrane-bound vacuole in epithelial cells of the gut and gallbladder. Although …

Coxiella burnetii infects mononuclear phagocytes, where it directs biogenesis of a vacuolar
niche termed the parasitophorous vacuole (PV). Owing to its lumenal pH (∼5) and fusion …

Salmonella enterica serovar Typhimurium invades and proliferates within epithelial cells.
Intracellular bacteria replicate within a membrane bound vacuole known as the Salmonella …

Salmonella Typhimurium is a facultative intracellular pathogen that causes acute gastroenteritis
in man. Intracellular Salmonella survive and replicate within a modified phagosome …

The Gram-negative bacterium Salmonella enterica has developed an array of sophisticated
tools to manipulate the host cell and establish an intracellular niche, for successful …