Clostridium difficile is the main causative agent of antibiotic-associated and health care-associated
infective diarrhea. Recently, there has been growing interest in alternative sources of …

Clostridium difficile is a pathogen responsible for diarrhoea and colitis, particularly after
antibiotic treatment. We evaluated the C. difficile protease Cwp84, found to be associated with …

Clostridium difficile pathogenicity is mediated mainly by its A and B toxins, but the colonization
process is thought to be a necessary preliminary step in the course of infection. The aim of …

Clostridium difficile is a pathogen which is responsible for diarrhea and colitis, particularly
after treatment with antibiotics. Clinical signs are mainly due to two toxins, TcdA and TcdB. …

Sera from patients with Clostridium difficile-associated disease (CDAD) and sera from a
control group were analysed by an ELISA to detect antibodies directed against four surface …

Pathogen attachment is a crucial early step in mucosal infections. This step is mediated by
important virulence factors, such as surface proteins. Clostridium difficile surface proteins …

Clostridium difficile pathogenesis is mainly due to toxins A and B. However, the first step of
pathogenesis is the colonization process. We evaluated C. difficile surface proteins as …

The immunogenicity of bacterial flagellin has been reported in different studies. By its close
interaction with the immune system, the flagellin represents an interesting adjuvant and …

New therapies are needed to prevent and treat Clostridium difficile infection and to limit the
rise in antibiotic resistance. Besides toxins, several surface components have been …

The spectrum of Clostridium difficile infections is highly variable, ranging from asymptomatic
carriage to fatal colitis depending on the strain virulence and on the host, its gut microbiota …