Although compensatory islet hyperplasia in response to insulin resistance is a recognized
feature in diabetes, the factor(s) that promote β cell proliferation have been elusive. We …

Restoring functional β-cell mass is an important therapeutic goal for both type 1 and type 2
diabetes ( 1 ). While proliferation of existing β-cells is the primary means of β-cell replacement …

The regulation of islet cell biology is critical for glucose homeostasis 1 . N 6 -methyladenosine
(m 6 A) is the most abundant internal messenger RNA (mRNA) modification in mammals 2 …

Type 1 diabetes is characterized by infiltration of pancreatic islets with immune cells, leading
to insulin deficiency. Although infiltrating immune cells are traditionally considered to …

MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic
form of diabetes associated with mutations in the carboxyl ester lipase (CEL) gene expressed …

The identification of new sources of β cells is an important endeavor with therapeutic
implications for diabetes. Insulin resistance, in physiological states such as pregnancy or in …

Background Human pancreatic islets are a central focus of research in metabolic studies.
Transcriptomics is frequently used to interrogate alterations in cultured human islet cells using …

Type 1 diabetes (T1D) is characterized by pancreatic islet infiltration by autoreactive immune
cells and a nearly complete loss of β cells 1. Restoration of insulin-producing β cells …

Studies in both humans and rodents suggest that maternal diabetes leads to a higher risk of
the fetus developing impaired glucose tolerance and obesity during adulthood. However, …

Type 1 diabetes (T1D) is characterized by the destruction of pancreatic β-cells. Several
observations have renewed the interest in β-cell RNA sensors and editors. Here, we report that N …