RNA sequencing is an increasingly popular technology for genome-wide analysis of
transcript sequence and abundance. However, understanding of the sources of technical and …

Pharmacogenomics is a key component of personalized medicine that promises safer and
more effective drug treatment by individualizing drug choice and dose based on genetic …

Background Folsomia candida is a model in soil biology, belonging to the family of Isotomidae,
subclass Collembola. It reproduces parthenogenetically in the presence of Wolbachia, …

Background The multifaceted control of gene expression requires tight coordination of
regulatory mechanisms at transcriptional and post-transcriptional level. Here, we studied the …

Cytochrome P450 2D6 (CYP2D6) is among the most important genes involved in drug
metabolism. Specific variants are associated with changes in the enzyme's amount and activity. …

Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disorder characterized by
ptosis, dysphagia and proximal limb weakness. Autosomal-dominant OPMD is caused by a …

Background Clostridium difficile strain 630Δerm is a spontaneous erythromycin sensitive
derivative of the reference strain 630 obtained by serial passaging in antibiotic-free media. It is …

Collembola (springtails) are detritivorous hexapods that inhabit the soil and its litter layer.
The ecology of the springtail Orchesella cincta is extensively studied in the context of …

A genetic diagnosis of autosomal‐dominant polycystic kidney disease (ADPKD) is challenging
due to allelic heterogeneity, high GC content, and homology of the PKD1 gene with six …

The use of pharmacogenomics in clinical practice is becoming standard of care. However,
due to the complex genetic makeup of pharmacogenes, not all genetic variation is currently …