Peptide nucleic acid (PNA) is a nucleobase oligomer in which the entire backbone has been
replaced by a backbone composed of N‐(2‐aminoethyl)glycine units. In other words, PNA …

Vertebrate DNA crosslink repair excises toxic replication-blocking DNA crosslinks.
Numerous factors involved in crosslink repair have been identified, and mutations in their …

The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and
chemotherapy-induced DNA crosslinks, and responds to replication stress 1 , 2 . Genetic …

Assembly of the major viral pathogens of the Picornaviridae family is poorly understood.
Human parechovirus 1 is an example of such viruses that contains 60 short regions of ordered …

DNA interstrand cross-links are tumor-inducing lesions that block DNA replication and
transcription. When cross-links are detected at stalled replication forks, ATR kinase …

Coxsackievirus A7 (CAV7) is a rarely detected and poorly characterized serotype of the
Enterovirus species Human enterovirus A (HEV-A) within the Picornaviridae family. The CAV7-…

Coxsackievirus A9 (CVA9) is an important pathogen of the Picornaviridae family. It utilizes
cellular receptors from the integrin α v family for binding to its host cells prior to entry and …

The poorly studied picornavirus, human parechovirus 3 (HPeV3) causes neonatal sepsis
with no therapies available. Our 4.3-Å resolution structure of HPeV3 on its own and at 15 Å …

Since it was first recognized in 2004 that human parechoviruses (HPeV) are a significant
cause of central nervous system and neonatal sepsis, their clinical importance, primarily in …

Highlights • CryoEM maps at medium (3.5–6 Å) resolution can be challenging to interpret. •
Integration of multiple methods can inform cryoEM studies. • Mass spectrometry and …