L-Glutamine (Gln) functions physiologically to balance the carbon and nitrogen requirements
of tissues. It has been proposed that in cancer cells undergoing aerobic glycolysis, …

During apoptosis, the mitochondrial outer membrane is permeabilized, leading to the
release of cytochrome c that activates downstream caspases. Mitochondrial outer membrane …

Glioblastoma is the most common form of primary brain tumor in adults and is essentially
incurable. Despite aggressive treatment regimens centered on radiotherapy, tumor recurrence …

Inhibition of the MDM2-p53 interaction has been shown to produce an antitumor effect,
especially in MDM2 amplified tumors. The isoindolinone scaffold has proved to be versatile for …

From a set of weakly potent lead compounds, using in silico screening and small library
synthesis, a series of 2-alkyl-3-aryl-3-alkoxyisoindolinones has been identified as inhibitors of …

Glioblastoma (GBM) is a lethal primary brain tumor characterized by treatment resistance
and inevitable tumor recurrence, both of which are driven by a subpopulation of GBM cancer …

Resistance to radiotherapy in glioblastoma (GBM) is an important clinical problem and several
authors have attributed this to a subpopulation of GBM cancer stem cells (CSCs) which …

A series of 2-N-alkyl-3-aryl-3-alkoxyisoindolinones has been synthesised and evaluated as
inhibitors of the MDM2–p53 interaction. The most potent compound, 3-(4-chlorophenyl)-3-(4-…

Glioblastoma multiforme lacks effective therapy options. Although deregulated kinase
pathways are drivers of malignant progression in glioblastoma multiforme, glioma cells exhibit …

Background The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of
stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-…