Conantokins are ∼20-amino acid peptides present in predatory marine snail venoms that
function as allosteric antagonists of ion channels of the N-methyl-d-aspartate receptor (…

Three members of a family of small neurotoxic peptides from the venom of Conus parius,
conantokins (Con) Pr1, Pr2, and Pr3, function as antagonists of N-methyl-D-aspartate receptors …

Background Patients with drug refractory temporal lobe epilepsy frequently accumulate
cognitive impairment over time, suggesting loss of neurons induced by seizures. Our objective …

Conantokins (con) are short γ-carboxyglutamate (Gla)-containing polypeptides expressed
by marine snails that function as antagonists of N-methyl-d-aspartate receptor (NMDAR) ion …

Conantokins, which are neuroactive peptides found in the venom of marine snails, contain
post-translationally modified γ-carboxyglutamate residues (Gla; γ). The Gla residues are …

Patients with drug refractory temporal lobe epilepsy frequently accumulate cognitive impairment
over time, suggesting neuronal loss induced by seizures. We measured serum levels of …

Conantokins are neuroactive peptides found in the venom of marine snails, containing post‐translationally
modified γ‐carboxyglutamate residues (γ). The γ residues are integral for …

Epilepsy is a chronic neurologic disorder characterized by recurrent seizures and variable
cognitive and neurodevelopmental issues. In many individuals the underlying pathogenesis is …

How do two seemingly distinct ways of thinking and acting – one premised on the belief that
some people are inherently more privileged than others and the second that endows each …

The majority of proteins have multiple independently folding and functioning domains; this
is known as protein modularity. Most of these molecular machines are tethered together by …