Background Artemisinin-resistant falciparum malaria has arisen in western Cambodia. A
concerted international effort is underway to contain artemisinin-resistant Plasmodium …

Here we present molecular evidence demonstrating that malaria parasites bearing high-level
pyrimethamine resistance originally arrived in Africa from southeast Asia. The resistance …

Background Emergence of artemisinin resistance in southeast Asia poses a serious threat
to the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has …

Evolving resistance to artemisinin-based compounds threatens to derail attempts to control
malaria. Resistance has been confirmed in western Cambodia and has recently emerged in …

Malaria parasites (Plasmodium falciparum) provide an excellent system in which to study the
genomic effects of strong selection in a recombining eukaryote because the rapid spread of …

Background . Our study examined the relative contributions of host, pharmacokinetic, and
parasitological factors in determining the therapeutic response to artemether-lumefantrine (AL)…

Background. Relapses originating from hypnozoites are characteristic of Plasmodium vivax
infections. Thus, reappearance of parasitemia after treatment can result from relapse, …

Background. Deployment of mefloquine–artesunate (MAS3) on the Thailand–Myanmar border
has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has …

Copy number polymorphism (CNP) is ubiquitous in eukaryotic genomes, but the degree to
which this reflects the action of positive selection is poorly understood. The first gene in the …

In western Cambodia, malaria parasites clear slowly from the blood after treatment with
artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors …