Acute bacterial infections are often treated empirically, with the choice of antibiotic therapy
updated during treatment. The effects of such rapid antibiotic switching on the evolution of …

Flagellar motility is critical for surface attachment and biofilm formation in many bacteria. A
key regulator of flagellar motility in Pseudomonas aeruginosa and other microbes is cyclic …

To initiate biofilm formation, it is critical for bacteria to sense a surface and respond precisely
to activate downstream components of the biofilm program. Type 4 pili (T4P) and increasing …

Most microbes in the biosphere are attached to surfaces, where they experience mechanical
forces due to hydrodynamic flow and cell-to-substratum interactions. These forces likely …

During biofilm formation, the opportunistic pathogen Pseudomonas aeruginosa uses its
type IV pili (TFP) to sense a surface, eliciting increased second-messenger production and …

Aim: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine, which has
been shown to promote disease severity in cystic fibrosis. Methods: In this study, aerosolized …

Attachment of bacteria onto a surface, consequent signaling, and accumulation and growth
of the surface-bound bacterial population are key initial steps in the formation of pathogenic …

It is now known that there exist multifactorial influences on swarming motility for P. aeruginosa
, but it is not clear precisely why stator selection in the flagellum motor is so important. We …

The downregulation of Pseudomonas aeruginosa flagellar motility is a key event in biofilm
formation, host colonization, and the formation of microbial communities, but the external …

… Λ s ), so that a larger tree symmetry value corresponds to a larger portion of a lineage persisting
on the surface: Λ s … stays on the surface after division; Λ s = 1 corresponds to a perfectly “…