We investigated the role of B cells in tumor immunity by studying immune responses of mice
genetically lacking B cells to primary tumors. IgM −/− B cell‐deficient mice (BCDM) exhibited …

The incorporation of rituximab, a chimeric anti-CD20 monoclonal antibody, into the therapeutic
armamentarium for patients with follicular lymphoma (FL) has significantly improved …

Synthetic triterpenoids are multitarget compounds exhibiting promise as preventative and
therapeutic agents for cancer. Their proposed mechanism of action is by forming Michael …

Our previous work has demonstrated that human follicular lymphoma (FL) infiltrating T cells
are anergic, in part due to suppression by regulatory T cells. In this study, we identify …

Regulatory T cells (TR) play a critical role in the inhibition of self-reactive immune responses
and as such have been implicated in the suppression of tumor-reactive effector T cells. In …

Many rigorous studies have shown that early childhood infections leave a lasting imprint on
the immune system. The understanding of this phenomenon has expanded significantly …

Multiomics profiling provides a holistic picture of a condition being examined and captures
the complexity of signaling events, beginning from the original cause (environmental or …

For quantitative proteomics, efficient, robust, and reproducible sample preparation with high
throughput is critical yet challenging, especially when large cohorts are involved, as is often …

Background There has been much interest in targeting intracellular redox pathways as a
therapeutic approach for cancer. Given recent data to suggest that the redox status of …

… Adjustment for multiple comparisons over dose combinations via control of the false
discovery rate was considered but deemed unnecessary, given that the majority of the synergy p …