Human lungs enable efficient gas exchange and form an interface with the environment, which
depends on mucosal immunity for protection against infectious agents. Tightly controlled …

Background Epigenetic mechanisms could alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that …

Background Chronic obstructive pulmonary disease (COPD) is a progressive, incurable lung
disease characterised by abnormal tissue repair causing emphysema and small airways …

Background Epigenetic signatures in the nasal epithelium, which is a primary interface with
the environment and an accessible proxy for the bronchial epithelium, might provide insights …

The IL1RL1 (ST2) gene locus is robustly associated with asthma; however, the contribution
of single nucleotide polymorphisms (SNPs) in this locus to specific asthma subtypes and the …

To the Editor: Respiratory disease, characterized by changes in the cells of the lung, can affect
molecular phenotype of cells and the intercellular interactions, resulting in a disbalance in …

To the Editor, Inhaled corticosteroids (ICS) improve asthma control in most, but not all patients.
1, 2 Currently, biomarkers that help clinicians to pre‐dict individual ICS responsiveness or …

Asthma is a chronic inflammatory disease with structural changes in the airway wall, including
goblet cell metaplasia, loss of ciliated epithelial cells, basement membrane thickening and …

Background: Epigenetic mechanisms may alter the airway epithelial barrier and ultimately
lead to atopic diseases such as asthma. Here we aim to identify DNA methylation profiles that …

BACKGROUND: Up to 10-12% of US children and adolescents report respiratory or skin
allergies. Epigenetic mechanisms may alter the airway epithelial barrier and ultimately lead to …