Patterns of recurrence and survival in sporadic, neurofibromatosis type 1–associated, and radiation-associated malignant peripheral nerve sheath tumors
…, CM Kivlin, DR Ingram, SM Landers… - Journal of …, 2017 - thejns.org
OBJECTIVE Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive group
of soft tissue sarcomas that can arise sporadically, in the context of neurofibromatosis Type 1 …
of soft tissue sarcomas that can arise sporadically, in the context of neurofibromatosis Type 1 …
Enhancer reprogramming in PRC2-deficient malignant peripheral nerve sheath tumors induces a targetable de-differentiated state
Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that
frequently harbor genetic alterations in polycomb repressor complex 2 (PRC2) components—SUZ12 …
frequently harbor genetic alterations in polycomb repressor complex 2 (PRC2) components—SUZ12 …
[HTML][HTML] AXL is a potential therapeutic target in dedifferentiated and pleomorphic liposarcomas
CD May, J Garnett, XY Ma, SM Landers, DR Ingram… - BMC cancer, 2015 - Springer
Background AXL is a well-characterized, protumorigenic receptor tyrosine kinase that is
highly expressed and activated in numerous human carcinomas and sarcomas, including …
highly expressed and activated in numerous human carcinomas and sarcomas, including …
[HTML][HTML] Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor
AD Bhalla, SM Landers, AK Singh, JP Landry… - Laboratory …, 2022 - Elsevier
Undifferentiated pleomorphic sarcoma (UPS) and malignant peripheral nerve sheath tumor (MPNST)
are aggressive soft tissue sarcomas that do not respond well to current treatment …
are aggressive soft tissue sarcomas that do not respond well to current treatment …
Co-targeting PI3K, mTOR, and IGF1R with small molecule inhibitors for treating undifferentiated pleomorphic sarcoma
CD May, SM Landers, S Bolshakov, XY Ma… - Cancer biology & …, 2017 - Taylor & Francis
Undifferentiated pleomorphic sarcomas (UPSs) are aggressive mesenchymal malignancies
with no definitive cell of origin or specific recurrent genetic hallmarks. These tumors are …
with no definitive cell of origin or specific recurrent genetic hallmarks. These tumors are …
She3p Possesses a Novel Activity Required for ASH1 mRNA Localization in Saccharomyces cerevisiae
SM Landers, MR Gallas, J Little, RM Long - Eukaryotic Cell, 2009 - Am Soc Microbiol
Intracellular and intercellular polarity requires that specific proteins be sorted to discreet
locations within and between cells. One mechanism for sorting proteins is through RNA …
locations within and between cells. One mechanism for sorting proteins is through RNA …
Poly (ADP) ribose polymerase inhibition: A potential treatment of malignant peripheral nerve sheath tumor
…, CD May, S Bolshakov, SM Landers… - Cancer Biology & …, 2016 - Taylor & Francis
Poly (ADP) ribose polymerase (PARP) inhibitors, first evaluated nearly a decade ago, are
primarily used in malignancies with known defects in DNA repair genes, such as alterations in …
primarily used in malignancies with known defects in DNA repair genes, such as alterations in …
Nonsense-Mediated Decay of ash1 Nonsense Transcripts in Saccharomyces cerevisiae
W Zheng, JS Finkel, SM Landers, RM Long… - Genetics, 2008 - academic.oup.com
Nonsense-mediated mRNA decay (NMD) performs two functions in eukaryotes, one in controlling
the expression level of a substantial subset of genes and the other in RNA surveillance…
the expression level of a substantial subset of genes and the other in RNA surveillance…
[HTML][HTML] AXL inhibition enhances MEK inhibitor sensitivity in malignant peripheral nerve sheath tumors
SM Landers, AD Bhalla, XY Ma, K Lusby… - Journal of cancer …, 2020 - ncbi.nlm.nih.gov
Dysregulation of the receptor tyrosine kinase AXL is known to promote cancer cell growth and
survival in many sarcomas, including the rare subtype, malignant peripheral nerve sheath …
survival in many sarcomas, including the rare subtype, malignant peripheral nerve sheath …
New cellular models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor
AD Bhalla, SM Landers, AK Singh, MG Yeagley… - bioRxiv, 2021 - biorxiv.org
Undifferentiated pleomorphic sarcoma (UPS) and malignant peripheral nerve sheath tumor (MPNST)
are aggressive soft tissue sarcomas that do not respond well to current treatment …
are aggressive soft tissue sarcomas that do not respond well to current treatment …