Recent findings in human samples and animal models support the involvement of
inflammation in the development of Parkinson’s disease. Nevertheless, it is currently unknown …

Friedreich’s ataxia (FRDA) is an autosomal-recessive neurodegenerative and cardiac
disorder which occurs when transcription of the FXN gene is silenced due to an excessive …

Current therapies remain unsatisfactory in preventing the recurrence of glioblastoma multiforme
(GBM), which leads to poor patient survival. By rational engineering of the transcription …

Wolfram syndrome 1 (WS1) is a rare genetic disorder caused by mutations in the WFS1 gene
leading to a wide spectrum of clinical dysfunctions, among which blindness, diabetes, and …

PBX1 regulates the balance between self-renewal and differentiation of hematopoietic stem
cells and maintains proto-oncogenic transcriptional pathways in early progenitors. Its …

Autosomal recessive osteopetrosis is a human bone disease mainly caused by TCIRG1
gene mutations that prevent osteoclasts resorbing activity, recapitulated by the oc/oc mouse …

Dravet Syndrome (DS) is mostly caused by heterozygous loss-of-function mutations in the
voltage-gated sodium channel SCN1A (Na v 1.1), thought to result in severe epilepsy and …

The balance between self-renewal and differentiation is crucial to ensure the homeostasis
of the hematopoietic system, and is a hallmark of hematopoietic stem cells. However, the …

… Simone Bido, 1 Sharon Muggeo, 1 Luca Massimino, 1 Matteo Jacopo Marzi, 2 Serena
Gea Giannelli, 1 Elena Melacini, 1, 3 Melania Nannoni, 1 Diana Gambarè, 1 Edoardo Bellini …

Both emerging viruses and well-known viral pathogens endowed with neurotropism can
either directly impair neuronal functions or induce physio-pathological changes by diffusing …