In response to stress, the heart undergoes extensive cardiac remodeling that results in
cardiac fibrosis and pathological growth of cardiomyocytes (hypertrophy), which contribute to …

Doxorubicin is one of the most potent chemotherapeutic agents. However, its clinical use is
restricted due to the severe risk of cardiotoxicity, partially attributed to elevated production of …

Background Pearl millet (Pennisetum glaucum) is a cereal crop that possesses the ability to
withstand drought, salinity and high temperature stresses. The NAC [NAM (No Apical …

Rationale: Cardiac fibroblasts (CFs) drive extracellular matrix remodeling after pressure
overload, leading to fibrosis and diastolic dysfunction. Recent studies described the role of long …

Rationale: RBPs (RNA-binding proteins) have been described to be expressed and regulated
in various organs including the heart. Little is known about the role of RBPs in heart failure …

Background : Aging populations show higher incidences of myocardial infarction (MI) and
heart failure (HF). Cardiac remodeling post-MI leads to progressive impaired cardiac function …

We would like to comment on a recent study that analyzed the role of microRNA-21 (miR-21)
in a mouse model of cardiac disease (1). Using miR-21–deficient mice and novel, very short…

Rationale Many processes in endothelial cells including angiogenic responses are regulated
by microRNAs. However, there is limited information available about their complex cross-…

Aims Cardiac transplantation is the only curative therapy for end-stage heart failure. Fibrosis
is one of the major causes for impaired function of cardiac allografts. MicroRNAs, a class of …

Rationale: In chronic heart failure, increased adrenergic activation contributes to structural
remodeling and altered gene expression. Although adrenergic signaling alters histone …