Context Most of what we know about antipsychotic drug effects is at the receptor level, distal
from the neural system effects that mediate their clinical efficacy. Studying cerebral function …

BACKGROUND: Schizophrenia and bipolar disorder share overlapping symptoms and
genetic etiology. Functional brain dysconnectivity is seen in both disorders. METHODS: We …

Conventional clinical neuroimaging is insensitive to axonal injury in traumatic brain injury (TBI).
Immunocytochemical staining reveals changes to axonal morphology within hours, …

Impulsivity, often defined as a human behavior characterized by the inclination of an
individual to act on urge rather than thought, with diminished regard to consequences, …

The brain’s default mode network (DMN) is highly heritable and is compromised in a variety
of psychiatric disorders. However, genetic control over the DMN in schizophrenia (SZ) and …

Background Schizophrenia and bipolar disorder share overlapping symptoms and risk genes.
Shared aberrant functional connectivity is hypothesized in both disorders and in relatives. …

BACKGROUND:: Substance-abusing individuals tend to display abnormal reward processing
and a vulnerability to being impulsive. Detoxified alcoholics show differences in regional …

Objective The study examined gray matter volume across psychosis diagnoses organized
by dimensional and DSM-IV categories from the Bipolar-Schizophrenia Network on …

Background Alcohol and marijuana are the two most abused substances in US colleges.
However, research on the combined influence (cross sectional or longitudinal) of these …

Background The current definitions of psychotic illness lack biological validity, motivating
alternative biomarker-driven disease entities. Building on experimental constructs—Biotypes—…