[HTML][HTML] The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models

…, CC Mak, M Ibanez, A Ghias, J Cahiwat, L Do, S Cho… - Cancer Letters, 2020 - Elsevier
The Wnt/β-catenin signaling pathway is aberrantly activated in colorectal (CRC) and many
other cancers, and novel strategies for effectively targeting it may be needed due to its …

[PDF][PDF] Oligogenic effects of 16p11. 2 copy-number variation on craniofacial development

…, H Li, SC Tang, E Richardson, O Hong, S Cho… - Cell reports, 2019 - cell.com
A copy-number variant (CNV) of 16p11.2 encompassing 30 genes is associated with
developmental and psychiatric disorders, head size, and body mass. The genetic mechanisms that …

The influence of microdeletions and microduplications of 16p11. 2 on global transcription profiles

…, SL Christian, H Peeters, SS Cho… - Journal of child …, 2015 - journals.sagepub.com
Copy number variants (CNVs) of a 600 kb region on 16p11.2 are associated with
neurodevelopmental disorders and changes in brain volume. The authors hypothesize that abnormal …

[PDF][PDF] Isolated Hypoglossal Nerve Palsy Secondary to Oligosecretory Multiple Myeloma

…, S Cho, AS Sidhu, J Chang, F Lui, B Muhar, SS Cho… - Cureus, 2023 - cureus.com
Isolated hypoglossal nerve (CN XII) palsy is rare. Neurological complications of multiple
myeloma (MM) are quite common, most often due to hyperviscosity and paraprotein-related …

Effects of SM08502, a novel, oral small-molecule inhibitor of Wnt pathway signaling, on gene expression and antitumor activity in colorectal cancer (CRC) models.

…, E Creger, B Eastman, CC Mak, L Do, S Cho… - 2019 - ascopubs.org
e15185 Background: Aberrant activation of Wnt signaling contributing to tumorigenesis is
most commonly associated with CRC (90% harbor Wnt pathway mutations). SM08502, a novel…

Transcriptome analysis of TCGA prostate cancer samples identifies an association of poorer survival and aggressive disease biology with CDC-like kinase (CLK) …

S Cho, AD Choudhury, C Fleener, L Do, C Bossard… - Cancer Research, 2020 - AACR
In prostate cancer, alternative splicing of mRNA and spliceosome activity are implicated in
several areas of disease pathogenesis. This is exemplified by the strong association of …

[PDF][PDF] Team 4-Rescue Drone

A Borgesen, P Burchell, C Campbell, S Cho, S Hood… - web1.eng.famu.fsu.edu
UAVs used by Florida State University’s Emergency Management and Homeland Security
Program can autonomously scan an area, but will provide no feedback regarding image …

OP0072 INHIBITION OF CLK2 AND DYRK1A BY SM04690 AS A NOVEL MOLECULAR REGULATOR OF WNT SIGNALING, CHONDROGENESIS, AND …

…, L Lamangan, M Ibanez, A Ghias, C Lai, L Do, S Cho… - 2019 - ard.bmj.com
Background In the synovial joint, Wnt pathway upregulation contributes to osteoarthritis (OA)
by increasing osteocyte differentiation, cartilage thinning, and inflammation. SM04690, a …

[PDF][PDF] Fall Final Report

A Borgesen, P Burchell, C Campbell, S Cho, S Hood… - eng-web1.eng.famu.fsu.edu
… Alexandra Borgesen Peter Burchell Cody Campbell Shawn Cho Sarah Hood Halil Yonter …
Shawn Cho is overseeing development and updating of the website, flight navigation and user …

[HTML][HTML] Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee …

…, M Ibanez, A Ghias, C Lai, L Do, S Cho… - Osteoarthritis and …, 2019 - Elsevier
Objectives Wnt pathway upregulation contributes to knee osteoarthritis (OA) through osteoblast
differentiation, increased catabolic enzymes, and inflammation. The small-molecule Wnt …