Autism spectrum disorders (ASD) are believed to have genetic and environmental origins,
yet in only a modest fraction of individuals can specific causes be identified 1 , 2 . To identify …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

A sudden increase in permeability of the inner mitochondrial membrane, the so-called
mitochondrial permeability transition, is a common feature of apoptosis and is mediated by the …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …

Lineage mapping has identified both proliferative and quiescent intestinal stem cells, but the
molecular circuitry controlling stem cell quiescence is incompletely understood. By lineage …

The term next-generation sequencing is almost a decade old, but it remains the colloquial
way to describe highly parallel or high-output sequencing methods that produce data at or …

Two‐dimensional difference gel electrophoresis (2‐D DIGE) coupled with mass spectrometry
(MS) was used to investigate tumor‐specific changes in the proteome of human colorectal …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …

Background Familial diarrhea disorders are, in most cases, severe and caused by recessive
mutations. We describe the cause of a novel dominant disease in 32 members of a …