We have identified two synthetic oligonucleotides (aptamers) that bind to prostate cancer
cells,with low nanomolar affinity, via the extracellular portion of the prostate-specificmembrane …

The tumor suppressor gene product p53 plays an important role in the cellular response to
DNA damage from exogenous chemical and physical mutagens. Therefore, we hypothesized …

Androgen receptor (AR)–mediated oncogenic pathways have not been fully elucidated. In
this study, we used high-throughput microarray analysis on two AR-positive prostate cancer (…

Aptamers are a special class of nucleic acid molecules that are beginning to be investigated
for clinical use. These small RNA/DNA molecules can form secondary and tertiary structures …

The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target
for imaging and therapy of cancer. We prepared seven 99m Tc/Re-labeled compounds by …

To extend our development of new imaging agents targeting the prostate-specific
membrane antigen (PSMA), we have used the versatile intermediate 2-[3-(5-amino-1-carboxy-pentyl)-…

MicroRNAs (miRNAs) are a natural part of the most recently discovered and global regulatory
pathway known as RNA interference. Functional studies have shown how specific miRNAs …

The molecular pathway of p53-dependent apoptosis (programmed cell death) is poorly
understood. Because p53 binds to the basal transcription-repair complex TFIIH and modulates its …

Dose-escalated radiation therapy for localized prostate cancer (PCa) has a clear therapeutic
benefit; however, escalated doses may also increase injury to noncancerous tissues. …

We describe a platform for dual modality (radionuclide/optical) imaging of prostate cancer (PCa)
based on targeting the prostate-specific membrane antigen (PSMA). An example …