User profiles for Shawn M. Lyons
Shawn M LyonsBoston University School of Medicine Verified email at bu.edu Cited by 3539 |
[PDF][PDF] Competing protein-RNA interaction networks control multiphase intracellular organization
Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates
such as those associated with RNA processing, but the rules that dictate their assembly, …
such as those associated with RNA processing, but the rules that dictate their assembly, …
RNA G-quadruplexes in biology: principles and molecular mechanisms
G-quadruplexes (G4s) are extremely stable DNA or RNA secondary structures formed by
sequences rich in guanine. These structures are implicated in many essential cellular …
sequences rich in guanine. These structures are implicated in many essential cellular …
Stress-specific differences in assembly and composition of stress granules and related foci
Cells have developed different mechanisms to respond to stress, including the formation of
cytoplasmic foci known as stress granules (SGs). SGs are dynamic and formed as a result of …
cytoplasmic foci known as stress granules (SGs). SGs are dynamic and formed as a result of …
YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression
SM Lyons, C Achorn, NL Kedersha… - Nucleic acids …, 2016 - academic.oup.com
Stress-induced angiogenin (ANG)-mediated tRNA cleavage promotes a cascade of cellular
events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and …
events that starts with production of tRNA-derived stress-induced RNAs (tiRNAs) and …
[HTML][HTML] Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs
RNA G-quadruplex (RG4) structures are involved in multiple biological processes. Recent
genome-wide analyses of human mRNA transcriptome identified thousands of putative …
genome-wide analyses of human mRNA transcriptome identified thousands of putative …
[PDF][PDF] The long non-coding RNA HIF1A-AS2 facilitates the maintenance of mesenchymal glioblastoma stem-like cells in hypoxic niches
Long non-coding RNAs (lncRNAs) have an undefined role in the pathobiology of glioblastoma
multiforme (GBM). These tumors are genetically and phenotypically heterogeneous with …
multiforme (GBM). These tumors are genetically and phenotypically heterogeneous with …
The role of RNA modifications in the regulation of tRNA cleavage
Transfer RNA (tRNA) have been harbingers of many paradigms in RNA biology. They are
among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA …
among the first recognized noncoding RNA (ncRNA) playing fundamental roles in RNA …
RNA biology of angiogenin: Current state and perspectives
SM Lyons, MM Fay, Y Akiyama, PJ Anderson… - RNA biology, 2017 - Taylor & Francis
Angiogenin (ANG) is a secreted ribonuclease best known for its ability to promote formation
of blood vessels. Extensive research over many years has elucidated its structure and …
of blood vessels. Extensive research over many years has elucidated its structure and …
eIF4G has intrinsic G-quadruplex binding activity that is required for tiRNA function
As cells encounter adverse environmental conditions, such as hypoxia, oxidative stress or
nutrient deprivation, they trigger stress response pathways to protect themselves until …
nutrient deprivation, they trigger stress response pathways to protect themselves until …
[PDF][PDF] Actionable cytopathogenic host responses of human alveolar type 2 cells to SARS-CoV-2
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic …
causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic …