To investigate the behavioral mechanism of chemotaxis inCaenorhabditis elegans, we recorded
the instantaneous position, speed, and turning rate of single worms as a function of time …

Little is known about the physiology of neurons in Caenorhabditis elegans. Using new
techniques for in situ patch-clamp recording in C. elegans, we analyzed the electrical properties …

Chemotaxis in Caenorhabditis elegans, like chemotaxis in bacteria 1 , involves a random
walk biased by the time derivative of attractant concentration 2 , 3 , but how the derivative is …

With a nervous system of only 302 neurons, the free-living nematode Caenorhabditis elegans
is a powerful experimental organism for neurobiology. However, the laboratory substrate …

Understanding rhythmic behavior at the developmental and genetic levels has important
implications for neurobiology, medicine, evolution, and robotics. We studied rhythmic behavior…

The ability to discriminate between different chemical stimuli is crucial for food detection,
spatial orientation and other adaptive behaviours in animals. In the nematode Caenorhabditis …

Non-invasive recording in untethered animals is arguably the ultimate step in the analysis of
neuronal function, but such recordings remain elusive. To address this problem, we devised …

This paper describes the fabrication and use of a microfluidic device for performing whole-animal
chemical screens using non-invasive electrophysiological readouts of neuromuscular …

Background The conserved DOS-motif proteins OSM-7 and OSM-11 function as coligands
with canonical DSL (Delta, Serrate, and LAG-2) ligands to activate C. elegans Notch …

10.7554/eLife.12572.001 Random search is a behavioral strategy used by organisms from
bacteria to humans to locate food that is randomly distributed and undetectable at a distance. …