[HTML][HTML] Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes
The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies
for complex diseases. Its application for genetic and epigenetic therapies in humans raises …
for complex diseases. Its application for genetic and epigenetic therapies in humans raises …
[HTML][HTML] Severe acute respiratory syndrome coronavirus 2 transmission potential, Iran, 2020
K Muniz-Rodriguez, ICH Fung, SR Ferdosi… - Emerging infectious …, 2020 - ncbi.nlm.nih.gov
To determine the transmission potential of severe acute respiratory syndrome coronavirus 2
in Iran in 2020, we estimated the reproduction number as 4.4 (95% CI 3.9–4.9) by using a …
in Iran in 2020, we estimated the reproduction number as 4.4 (95% CI 3.9–4.9) by using a …
Transmission potential of COVID-19 in Iran
We computed reproduction number of COVID-19 epidemic in Iran using two different methods.
We estimated R 0 at 3.6 (95% CI, 3.2, 4.2) (generalized growth model) and at 3.58 (95% …
We estimated R 0 at 3.6 (95% CI, 3.2, 4.2) (generalized growth model) and at 3.58 (95% …
Retracted: PTEN loss drives resistance to the neddylation inhibitor MLN4924 in glioblastoma and can be overcome with TOP2A inhibitors
Background. Neddylation inhibition, affecting posttranslational protein function and turnover,
is a promising therapeutic approach to cancer. We report vulnerability to MLN4924 or …
is a promising therapeutic approach to cancer. We report vulnerability to MLN4924 or …
[PDF][PDF] Targeting an immortalization mutation to control glioblastoma
JS Iyer, SR Ferdosi, N Tang, V Gokhale… - Cancer …, 2020 - media.sparx-ip.net
Introduction Page 1 Glioblastoma multiforme (GBM), the most aggressive primary brain
tumor, is a very heterogeneous tumor, but its standard treatment of temozolomide and …
tumor, is a very heterogeneous tumor, but its standard treatment of temozolomide and …
Dynamic multi-OMICS analysis of glioblastoma cells reveals context of vulnerability to neddylation inhibition by pevonedistat
SR Ferdosi, B Taylor, N Tang, R Bybee, S Peng… - Cancer Research, 2019 - AACR
As the most lethal primary brain tumor, glioblastoma multiforme (GBM) calls for novel therapeutic
development. Global over activation of neddylation (a post-translational modification) …
development. Global over activation of neddylation (a post-translational modification) …
Non-canonical functions of TERT in glioblastoma pathobiology
Mutations in the promotor region of TERT are the most common non-coding mutations across
cancers, especially in glioblastoma (GBM), which has a TERT mutation frequency rate over …
cancers, especially in glioblastoma (GBM), which has a TERT mutation frequency rate over …
[BOOK][B] Genome-Driven Targeted Cancer Therapy
SR Ferdosi - 2017 - search.proquest.com
… performed with EdgeR package from Bioconductor v3.2 in R 3.2.3. Multi-dimensional scaling
(… Statistical analysis was performed by Microsoft Excel 2013 and GraphPad Prism 6.0 and R …
(… Statistical analysis was performed by Microsoft Excel 2013 and GraphPad Prism 6.0 and R …
CSIG-14. PTEN AS A SIGNATURE OF VULNERABILITY OF GBM TO NEDDYLATION INHIBITION
Neddylation is a specific pathway within the ubiquitin/proteasome system that is overactive
in GBM, and whose upregulation has been associated with glioma progression and worse …
in GBM, and whose upregulation has been associated with glioma progression and worse …
Underlying mechanism of response to neddylation inhibition in a subset of glioblastoma
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in
adults with a 5-year survival rate of ~3%. The ubiquitin/proteasome system maintains …
adults with a 5-year survival rate of ~3%. The ubiquitin/proteasome system maintains …