Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit
maps are increasingly available, knowledge of their underlying molecular networks remains …

Distal enhancers play pivotal roles in development and disease yet remain one of the least
understood regulatory elements. We used massively parallel reporter assays to perform …

Emergence of new viral agents is driven by evolution of interactions between viral proteins
and host targets. For instance, increased infectivity of SARS-CoV-2 compared to SARS-CoV-…

Each human genome carries tens of thousands of coding variants. The extent to which this
variation is functional and the mechanisms by which they exert their influence remains largely …

Significant efforts have been devoted in the last decade to improving molecular docking
techniques to predict both accurate binding poses and ranking affinities. Some shortcomings in …

Thorough quality assessment of novel interactions identified by proteome-wide cross-linking
mass spectrometry (XL-MS) studies is critical. Almost all current XL-MS studies have …

Systematic mappings of protein interactome networks have provided invaluable functional
information for numerous model organisms. Here we develop PCR-mediated Linkage of …

Rapid advances in next-generation sequencing technology have resulted in an explosion of
whole-exome/genome sequencing data, providing an unprecedented opportunity to identify …

The recent COVID-19 pandemic has sparked a global public health crisis. Vital to the
development of informed treatments for this disease is a comprehensive understanding of the …

Rapid accumulation of cancer genomic data has led to the identification of an increasing
number of mutational hotspots with uncharacterized significance. Here we present a …