Short open reading frames (sORFs) are a common feature of all genomes, but their coding
potential has mostly been disregarded, partly because of the difficulty in determining whether …

Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex (MTBC…

Background Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder
and the most common form of dementia. AD is highly heritable, with heritability estimates …

Background Alzheimer's disease is a debilitating and highly heritable neurological condition.
As such, genetic studies have sought to understand the genetic architecture of Alzheimer's …

Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

GWAS summary statistics are fundamental for a variety of research applications yet no
common storage format has been widely adopted. Existing tabular formats ambiguously or …

Objective The purpose of this study was to infer causal relationships between 22 previously
reported risk factors for Alzheimer's disease (AD) and the “AD phenome”: AD, AD age of …

Approximately 30% of older adults exhibit the neuropathological features of Alzheimer’s
disease without signs of cognitive impairment. Yet, little is known about the genetic factors that …

Importance Apolipoprotein E (APOE)*2 andAPOE*4 are, respectively, the strongest
protective and risk-increasing, common genetic variants for late-onset Alzheimer disease (AD), …

Background Idiopathic pulmonary fibrosis (IPF) is a complex lung disease, characterized by
progressive lung scarring. Severe COVID-19 is associated with substantial pneumonitis and …