User profiles for Shefah Qazi

Shefah Qazi

Indiana University
Verified email at indiana.edu
Cited by 820

Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading

J Lucon, S Qazi, M Uchida, GJ Bedwell, B LaFrance… - Nature …, 2012 - nature.com
Virus-like particles (VLPs) have emerged as important and versatile architectures for
chemical manipulation in the development of functional hybrid nanostructures. Here we …

Functional virus-based polymer–protein nanoparticles by atom transfer radical polymerization

…, K Breitenkamp, LO Liepold, S Qazi… - Journal of the …, 2011 - ACS Publications
Viruses and virus-like particles (VLPs) are useful tools in biomedical research. Their defined
structural attributes make them attractive platforms for engineered interactions over large …

Programmed self-assembly of an active P22-Cas9 nanocarrier system

S Qazi, HM Miettinen, RA Wilkinson… - Molecular …, 2016 - ACS Publications
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) RNA-guided
endonucleases are powerful new tools for targeted genome engineering. These nucleases provide …

P22 viral capsids as nanocomposite high-relaxivity MRI contrast agents

S Qazi, LO Liepold, MJ Abedin, B Johnson… - Molecular …, 2013 - ACS Publications
Attachment of multiple chelated Gd 3+ ions to the interior of bacteriophage P22 viral capsids
affords nanoscale MRI contrast agents with extremely high relaxivity values. Highly …

Revisiting an old friend: new findings in alphavirus structure and assembly

JM Button, SA Qazi, JCY Wang… - Current opinion in …, 2020 - Elsevier
Highlights • Both the E2 and E1 glycoproteins interact with the cellular Mxr8 receptor. • TF
virulence factor production correlates with structural polyprotein topology. • Some …

Manganese(III) porphyrins complexed with P22 virus-like particles as T 1-enhanced contrast agents for magnetic resonance imaging

S Qazi, M Uchida, R Usselman, R Shearer… - JBIC Journal of …, 2014 - Springer
Virus-like particles are powerful platforms for the development of functional hybrid materials.
Here, we have grown a cross-linked polymer (cross-linked aminoethyl methacrylate) within …

Gadolinium-loaded viral capsids as magnetic resonance imaging contrast agents

RJ Usselman, S Qazi, P Aggarwal, SS Eaton… - Applied magnetic …, 2015 - Springer
Polymeric nanohybrid P22 virus capsids were used as templates for high density Gd 3+
loading to explore magnetic field-dependent (0.5–7.0 T) proton relaxivity. The field-dependence …

An assembly-activating site in the hepatitis B virus capsid protein can also trigger disassembly

S Qazi, CJ Schlicksup, J Rittichier… - ACS chemical …, 2018 - ACS Publications
The Hepatitis B Virus (HBV) core protein homodimers self-assemble to form an icosahedral
capsid that packages the viral genome. Disassembly occurs in the nuclear basket to release …

Virion-associated polyamines transmit with bunyaviruses to maintain infectivity and promote entry

V Mastrodomenico, JJ Esin, S Qazi… - ACS Infectious …, 2020 - ACS Publications
Viruses require host cell metabolites to productively infect, and the mechanisms by which
viruses usurp these molecules are diverse. One group of cellular metabolites important in virus …

Changes in the stability and biomechanics of P22 bacteriophage capsid during maturation

R Kant, A Llauró, V Rayaprolu, S Qazi… - … et Biophysica Acta (BBA …, 2018 - Elsevier
The capsid of P22 bacteriophage undergoes a series of structural transitions during
maturation that guide it from spherical to icosahedral morphology. The transitions include the …