We have reviewed a battery of useful tests for evaluating sensorimotor function and plasticity
acutely and chronically in unilateral rat models of central nervous system injury. These tests …

Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's
disease. To investigate the pathogenic mechanism by which loss of parkin function causes …

Accumulation of α-synuclein in brain is a hallmark of synucleinopathies, neurodegenerative
diseases that include Parkinson's disease. Mice overexpressing α-synuclein under the Thy-…

We determined the effects of immobilization stress on rat colonic mucus release and mast cell
degranulation and examined whether corticotropin releasing factor (CRF) was involved in …

Mitochondrial toxins such as the complex 1 inhibitor rotenone are widely used as pesticides
and may be present in military environments. Administration of rotenone can induce …

Accumulation of α‐synuclein in neurons of the central and peripheral nervous system is a
hallmark of sporadic Parkinson’s disease (PD) and mutations that increase α‐synuclein levels …

Genetic mouse models based on identification of genes that cause Huntington's and
Parkinson's diseases have revolutionized understanding of the mechanistic pathophysiological …

Recessive mutations in parkin are the most common cause of familial early-onset Parkinson's
disease (PD). Recent studies suggest that certain parkin mutants may exert dominant toxic …

Parkinson's disease is a common neurodegenerative disorder characterized by a profound
motor disability that is traceable to the emergence of synchronous, rhythmic spiking in …

Sensitive and reliable behavioral outcome measures are essential to the evaluation of
potential therapeutic treatments in preclinical trials for many neurodegenerative diseases. In …