Generation of potent antibodies by a mutation-selection process called affinity maturation is
a key component of effective immune responses. Antibodies that protect against highly …

Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising
doubts as to whether they can be elicited by vaccination. We used 454 sequencing and …

We study the synchronization of dissipatively coupled van der Pol oscillators in the quantum
limit, when each oscillator is near its quantum ground state. Two quantum oscillators with …

Natural environments can present diverse challenges, but some genotypes remain fit across
many environments. Such “generalists” can be hard to evolve, outcompeted by specialists …

Biological organisms experience constantly changing environments, from sudden changes
in physiology brought about by feeding, to the regular rising and setting of the Sun, to …

Evolving systems, be it an antibody repertoire in the face of mutating pathogens or a microbial
population exposed to varied antibiotics, constantly search for adaptive solutions in time-…

Contractile forces are essential for many developmental processes involving cell shape
change and tissue deformation. Recent experiments on reconstituted actomyosin networks, the …

Affinity maturation is a Darwinian process in which B lymphocytes evolve potent antibodies
to encountered antigens and generate immune memory. Highly mutable complex pathogens …

Germinal centers (GCs) require sustained availability of antigens to promote antibody affinity
maturation against pathogens and vaccines. A key source of antigens for GC B cells are …

A systematic expansion of the many-body master equation for active matter, in which motors
power configurational changes as in the cytoskeleton, is shown to yield a description of the …