Examining the behavioral consequences of selective CNS neuronal activation is a powerful
tool for elucidating mammalian brain function in health and disease. Newly developed …

Three defining clinical symptoms of autism are aberrant reciprocal social interactions,
deficits in social communication, and repetitive behaviors, including motor stereotypies and …

Profound impairment in social interaction is a core symptom of autism, a severe neurodevelopmental
disorder. Deficits can include a lack of interest in social contact and low levels of …

Core symptoms of autism include deficits in social interaction, impaired communication, and
restricted, repetitive behaviors. The repetitive behavior domain encompasses abnormal …

At least 120 non-olfactory G-protein-coupled receptors in the human genome are ‘orphans’
for which endogenous ligands are unknown, and many have no selective ligands, hindering …

Oxytocin mediates social affiliation behaviors and social memory in rodents. It has been
suggested that disruptions in oxytocin contribute to the deficits in reciprocal social interactions …

Repetitive behavior, a core symptom of autism, encompasses stereotyped responses,
restricted interests, and resistance to change. These studies investigated whether different …

Reduced NMDA receptor function is hypothesized to contribute to the pathophysiology of
schizophrenia. In order to model chronic and developmental NMDA receptor hypofunction, a …

Synaptic consolidation is a process thought to consolidate memory in the brain. Although
lesion studies have mainly implicated the hippocampus (HPC) in this process, it is unknown …

Here, we describe a newly generated transgenic mouse in which the Gs DREADD (rM3Ds),
an engineered G protein-coupled receptor, is selectively expressed in striatopallidal medium …