Single-cell and single-nucleus RNA sequencing (sc/snRNA-seq) technologies have
enhanced the understanding of the molecular pathogenesis of neurodegenerative disorders, …

Emerging evidence indicates that cellular senescence could be a critical inducing factor for
aging-associated neurodegenerative disorders. However, the involvement of cellular …

BACKGROUND In recent years, neoadjuvant chemotherapy (NAC) has been increasingly
used in patients with resectable colorectal liver metastases. However, the efficacy and safety …

Impairment in glucocerebrosidase (GCase) is strongly associated with the development of
Parkinson's disease (PD), yet the regulators responsible for its impairment remain elusive. In …

Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that
resembles some of the symptoms of human depression. In the present study, we used a …

In this study, we investigated the mechanisms of 3′,4′,7-trihydroxyflavone (THF)
protection of neuronal cells from neuronal cell death induced by the oxidative stress-related …

Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension,
rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we …

Cold colorectal tumors are not likely to trigger a robust immune response and tend to
suppress the immune response. There may be three reasons. First, the complex tumor …

ETHNOPHARMACOLOGICAL RELEVANCE: Eucommia ulmoides Oliv. Bark. (EUE), has
commonly been used to fortify the muscles and lungs, lower blood pressure, prevent …

Parkinson’s disease (PD) is the second most common neurodegenerative disorder that results
in motor dysfunction and, eventually, cognitive impairment. α-Synuclein protein is known …